Negative+studies

SAMMPRIS (2011): Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis - treatment: percutaneous transluminal angioplasty and stenting (PTAS) and aggressive medical therapy - control: aggressive medical therapy - population: patients who had a recent TIA or stroke attributed to stenosis of 70 to 99% of the diameter of a major intracranial artery - method: RCT - follow-up: 11.9 months mean (ongoing) - primary end-point: stroke or death within 30 days after enrollment or after a revascularization procedure - outcome: stroke or death within 30 days after enrollment or after a revascularization procedure: treatment 14.7%, control 5.8%

COSS: Powers WJ, Clarke WR, Grubb RL, Videen TO, Adams HP Jr, Derdeyn CP, et al. Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial. //JAMA//. 2011;306:1983–1992. - RCT - n=195 - Subjects: Recent symptomatic atherosclerotic ICA occlusion within 120 days - Treatment: Extracranial-intracranial bypass (superficial temporal artery to an MCA branch) + medical management - Control: Medical management - Primary Outcome: Combined (1) stroke/death within 30 days of surgery or randomization to control group and (2) ipsilateral stroke within 2 years - Results: Terminated early for futility. 30 day rates for ipsilateral stroke were 14.4% in surgical group and 2.0% in control group. Two-year rates for primary end point were not significantly different.