Surgery+for+Epilepsy

ERSET: Engel et al, "Early Surgical Therapy for Drug-Resistant Temporal Lobe Epilepsy." JAMA 2012; 307:922. - RCT antiepileptic drugs (AEDs) vs anteromesial temporal resection (AMTR) - N=38 (planned enrollment 200, halted prematurely due to slow accrual) - Mesial temporal lobe epilepsy and disabling seizures for no more than 2 consecutive years following adequate trials of 2 brand-name AEDs - 0/23 pts in AED group and 11/15 pts in AMTR group were seizure free during year 2 of follow-up (P<0.001). - Notes: Small study, prematurely stopped because of slow accrual. 4/15 pts in AMTR group had memory decline.